NFL Week 4 Predictions & Picks

Doug Bonjour
Last Updated: Sep 28, 2023

We’re already on to Week 4 of the NFL season.

Last week’s slate featured a few big upsets, none greater than the Cardinals knocking off the Cowboys as nearly two-touchdown underdogs.

As we turn the page to Sunday, let’s look at a few of our favorite NFL Week 4 bets.

NFL Week 4 Predictions

All NFL betting odds used for these Week 4 predictions are current as of Tuesday, Sept. 26, and courtesy of DraftKings Sportsbook.

Commanders vs Eagles Prediction

Best Bet: PHI -8 (-108)

Sam Howell has displayed potential, but the Commanders have done an incredibly poor job protecting their second-year quarterback. Howell has already been sacked 19 times in three games, six more than anyone else.

In Sunday’s 37-3 loss to Buffalo, Howell threw four interceptions and was sacked nine times. That’s simply unsustainable.

If the Commanders can’t keep him upright, it’ll be a long day for Washington against the Eagles’ vaunted pass rush. Look for Philadelphia to win by multiple scores at home.

Ravens vs Browns Prediction

Best Bet: BAL +2.5 (-105)

In two home games, the Browns have yet to allow a touchdown. They’re coming off a 27-3 thumping of Tennessee, in which Ryan Tannehill was sacked five times.

But divisional games can be tricky, and this is no different.

After an upset loss to Indianapolis, this is a prime bounce-back opportunity for Baltimore. If nothing else, the Ravens will keep it close.

Four of the last five matchups between these teams have been decided by single digits. Take the visitors and the points in this AFC North showdown.

Broncos vs Bears Prediction

Best Bet: Under 46 (-110)

Yes, I know, the Broncos just gave up 70 points. But what have the Bears done to make anyone think they’ll score even a third of that? Chicago’s offense has been putrid.

The way things are going, the Bears will be in line for the No. 1 pick in next April’s draft. That is, of course, if the Broncos don’t beat them to it.

Both teams are 0-3. One of them will win. Regardless, it’ll be ugly.

Steelers vs Texans Prediction

Best Bet: PIT -3 (-112)

The Texans pulled off one of the biggest surprises of Week 3, upsetting the defending AFC South champion Jaguars 37-17.

C.J. Stroud has been impressive, recording a 64.5% completion rate and no interceptions over his first three starts. But now he gets the Steelers, who are far better defensively than anyone Houston has faced thus far.

Expect Minkah Fitzpatrick, T.J. Watt, and Co. to give the rookie first-rounder fits.

Raiders vs Chargers Prediction

Best Bet: LAC -6 (-112)

Given his familiarity with Josh McDaniels‘ scheme, Jimmy Garoppolo was supposed to elevate Las Vegas’ offense. Instead, through three weeks, the Raiders have scored a total of 45 points. That’s the third-fewest in the NFL.

On top of that, Garoppolo — who is now in concussion protocol — leads the league with six interceptions. If he can’t go, the Raiders will presumably turn to either veteran Brian Hoyer or rookie fourth-rounder Aiden O’Connell.

No matter who plays, it’s hard to trust Las Vegas. This feels like a safe bet so long as it stays under a touchdown.


Doug Bonjour

Doug covered college and prep sports in Connecticut for more than a decade, including stints as the UConn women’s basketball and UConn football beat reporter for Hearst Connecticut Media. During his time reporting on the 11-time national champion Huskies, he covered three NCAA Final Fours. He also has written for the Associated Press and New York Times.

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