It’s the most wonderful time of the year for NFL fans.
In this season of giving, the NFL is providing football fans with four days of games in Week 16, which coincides with Christmas Day.
Seven of the 16 games will be broadcast nationally, and with nearly every game having some playoff implications, the gift of football will be ours to enjoy.
Here’s a look at the Week 16 NFL odds and betting lines.
NFL Week 16 Odds & Betting Lines
All NFL betting odds cited below are current as of Monday, Dec. 18, and courtesy of DraftKings Sportsbook.
New Orleans Saints @ Los Angeles Rams
Thursday, Dec. 21, 8:15 p.m. ET
- Moneyline: Saints (+164) @ Rams (-198)
- Spread: Saints +4 (-110) @ Rams -4 (-110)
- Over/Under: Over 44.5 (-110) / Under 44.5 (-110)
The New Orleans Saints kept pace with the Tampa Bay Buccaneers for sole possession of first place in the NFC South, but they’re also battling the Los Angeles Rams for the final wild-card spot.
The winner of this TNF clash will have the tiebreaker over the loser. This game is huge.
Cincinnati Bengals @ Pittsburgh Steelers
Saturday, Dec. 23, 4:30 p.m. ET
- Moneyline: Bengals (-130) @ Steelers (+110)
- Spread: Bengals -2 (-110) @ Steelers +2 (-110)
- Over/Under: Over 39 (-110) / Under 39 (-110)
The Cincinnati Bengals scored a massive, come-from-behind home overtime win over the Minnesota Vikings to finally move out of the AFC North basement.
The Pittsburgh Steelers have dropped three straight, taking over last place in the division, and are fading fast.
Buffalo Bills @ Los Angeles Chargers
Saturday, Dec. 23, 8 p.m. ET
- Moneyline: Bills (-950) @ Chargers (+650)
- Spread: Bills -14 (-105) @ Chargers +14 (-115)
- Over/Under: Over 42.5 (-110) / Under 42.5 (-110)
The Los Angeles Chargers cleaned house by firing coach Brandon Staley after their embarrassing 42-point loss in Vegas on Thursday.
Giff Smith’s first test as interim coach will be the red-hot Buffalo Bills, who have won three of four, including a 21-point shellacking of the Dallas Cowboys on Sunday.
Green Bay Packers @ Carolina Panthers
Sunday, Dec. 24, 1 p.m. ET
- Moneyline: Packers (-218) @ Panthers (+180)
- Spread: Packers -4.5 (-110) @ Panthers -4 (-110)
- Over/Under: Over 36 (-110) / Under 36 (-110)
The Carolina Panthers treated the diehards that attended Sunday’s rain-soaked affair to their second win of the season over the rival Atlanta Falcons.
They’ll look to stay hot against the suddenly fading Green Bay Packers, who have dropped two straight.
Detroit Lions @ Minnesota Vikings
Sunday, Dec. 24, 1 p.m. ET
- Moneyline: Lions (-185) @ Vikings (+154)
- Spread: Lions -3.5 (-110) @ Vikings +3.5 (-110)
- Over/Under: Over 47 (-110) / Under 47 (-110)
The Detroit Lions rolled the Denver Broncos on Saturday night but have been a far-inferior team away from Ford Field.
Fortunately, the Vikings, who have dropped three of four and blown a double-digit lead in two of those, play in a climate-controlled stadium, too.
Washington Commanders @ New York Jets
Sunday, Dec. 24, 1 p.m. ET
- Moneyline: Commanders (+136) @ Jets (-162)
- Spread: Commanders +3 (-110) @ Jets -3 (-110)
- Over/Under: Over 38 (-110) / Under 38 (-110)
Here it is, the one game this weekend without playoff implications. My best advice is to take the Under.
Cleveland Browns @ Houston Texans
Sunday, Dec. 24, 1 p.m. ET
- Moneyline: Browns (+114) @ Texans (-135)
- Spread: Browns +2.5 (-110) @ Texans -2.5 (-110)
- Over/Under: Over 42 (-110) / Under 42 (-110)
Each team is coming off a huge, come-from-behind victory, with the Houston Texans claiming a road OT win behind backup quarterback Case Keenum.
Meanwhile, the Cleveland Browns keep winning with defense and backup Joe Flacco.
This game should be fun.
Indianapolis Colts @ Atlanta Falcons
Sunday, Dec. 24, 1 p.m. ET
- Moneyline: Colts (-135) @ Falcons (+114)
- Spread: Colts -2 (-110) @ Falcons +2 (-110)
- Over/Under: Over 44.5 (-110) / Under 44.5 (-110)
The Indianapolis Colts are surging, with five wins in their past six games, led by Gardner Minshew II.
Meanwhile, the Falcons lost a huge game in Carolina, their second straight divisional defeat, but remain within a game of the NFC South lead.
Seattle Seahawks @ Tennessee Titans
Sunday, Dec. 24, 1 p.m. ET
- Moneyline: Seahawks (-142) @ Titans (+120)
- Spread: Seahawks -2.5 (-110) @ Titans +2.5 (-110)
- Over/Under: Over 42.5 (-110) / Under 42.5 (-110)
The Tennessee Titans are tough in Nashville despite suffering two straight home overtime losses.
The Seattle Seahawks have not been good away from home, managing just a 2-5 road record, but they desperately need to win this game to keep pace in the NFC wild-card race.
Jacksonville Jaguars @ Tampa Bay Buccaneers
Sunday, Dec. 24, 4:05 p.m. ET
- Moneyline: Jaguars (-118) @ Buccaneers (-102)
- Spread: Jaguars -1 (-110) @ Buccaneers +1 (-110)
- Over/Under: Over 43.5 (-110) / Under 43.5 (-110)
The Bucs are hot with three straight wins. The Jacksonville Jaguars are not, with three straight losses.
Dallas Cowboys @ Miami Dolphins
Sunday, Dec. 24, 4:25 p.m. ET
- Moneyline: Cowboys (+102) @ Dolphins (-122)
- Spread: Cowboys +1.5 (-110) @ Dolphins -1.5 (-110)
- Over/Under: Over 51 (-110) / Under 51 (-110)
The Miami Dolphins finally looked like themselves, despite the absence of Tyreek Hill (ankle), in their 30-0 win over the New York Jets.
The Cowboys, who are just 3-4 on the road this season, will look to get right after a blowout loss to the Bills in Western New York.
Arizona Cardinals @ Chicago Bears
Sunday, Dec. 24, 4:25 p.m. ET
- Moneyline: Cardinals (+160) @ Bears (-192)
- Spread: Cardinals +4 (-110) @ Bears -4 (-110)
- Over/Under: Over 44.5 (-110) / Under 44.5 (-110)
The Chicago Bears’ faint playoff hopes took a huge hit with their gut-wrenching loss to the Browns. But they should be able to roll the Arizona Cardinals, who are 1-6 on the road this season.
New England Patriots @ Denver Broncos
Sunday, Dec. 24, 8:15 p.m. ET
- Moneyline: Patriots (+215) @ Broncos (-265)
- Spread: Patriots +6 (-110) @ Broncos -6 (-110)
- Over/Under: Over 36.5 (-110) / Under 36.5 (-110)
The Broncos’ playoff hopes were dealt a huge blow in Detroit. But they should feast on the New England Patriots, who are dead last in the AFC.
Las Vegas Raiders @ Kansas City Chiefs
Monday, Dec. 25, 1 p.m. ET
- Moneyline: Raiders (+380) @ Chiefs (-500)
- Spread: Raiders +10 (-110) @ Chiefs -10 (-110)
- Over/Under: Over 43 (-110) / Under 43 (-110)
The Kansas City Chiefs got right with a 10-point win over the hapless Patriots on Sunday and can give their fans a Christmas gift by clinching the AFC West for the eighth straight year if they beat the Las Vegas Raiders.
Vegas quarterback Aidan O’Connell will try to stay hot and stymie KC’s division-clinching party.
New York Giants @ Philadelphia Eagles
Monday, Dec. 25, 4:30 p.m. ET
- Moneyline: Giants (+455) @ Eagles (-625)
- Spread: Giants +10.5 (-110) @ Eagles -10.5 (-110)
- Over/Under: Over 43.5 (-110) / Under 43.5 (-110)
The Philadelphia Eagles have been eking out wins recently, but they have beaten the New York Giants four straight times and won 10 straight against Big Blue at Lincoln Financial Field.
New York’s three-game win streak was snapped in New Orleans, but it is still mathematically alive for the final NFC wild-card spot.
Baltimore Ravens @ San Francisco 49ers
Monday, Dec. 25, 8:15 p.m. ET
- Moneyline: Ravens (+180) @ 49ers (-218)
- Spread: Ravens +5 (-110) @ 49ers -5 (-110)
- Over/Under: Over 45.5 (-110) / Under 45.5 (-110)
The Baltimore Ravens were the first AFC team to clinch a playoff spot, but they will have their hands full with the San Francisco 49ers, who have won six straight by double digits and look like the best team in football.
This could be a potential Super Bowl preview.
NFL Week 16 Betting Trends
Here are some Week 16 betting trends to consider from the 2022 season:
- Favorites finished the week 10-6 straight up.
- Home teams were 8-8 straight up and 8-8 against the spread.
- Home favorites were 5-5 ATS, while home underdogs went 3-3.
- Unders won the week, going 10-6.