NFL Week 15 Predictions & Picks

Doug Bonjour
Last Updated: Dec 12, 2023

The NFL’s Week 15 slate features a bevy of prime-time games, including a triple-header on Saturday.

But, for these picks, we’re going to stick with the traditional Sunday slate.

There are a few games that stand out, with none bigger than the showdown in Buffalo between the Bills and Dallas Cowboys.

Will Dallas stay hot? We break down that and more in our NFL Week 15 best bets.

NFL Week 15 Predictions

All NFL betting odds used for these Week 15 predictions are current as of Tuesday, Dec. 12, and courtesy of DraftKings Sportsbook.

Falcons vs Panthers Prediction

Best Bet: ATL -3 (-112)

There appears to be no end in sight to the Carolina Panthers’ struggles. They have lost six straight to fall to 1-12 and are a league-worst 2-9-2 ATS.

Making matters worse, Bryce Young hasn’t shown any real signs of improvement, as the Panthers rank 30th in scoring (15.2 PPG).

The Atlanta Cardinals have had issues of their own, but they are the stronger play against a team that seemingly can’t do anything right.

Giants vs Saints Prediction

Best Bet: NYG +4.5 (-110)

Last month, the New York Giants’ season was deemed over following a 2-8 start that included a dismal 13-10 overtime loss to the New York Jets.

However, New York has flipped the script, winning three straight while discovering a new hero in Tommy DeVito. Now 5-8, the Giants sit just a game out of the final playoff spot in the NFC.

Look for that success to continue against the Saints, who are just 3-9-1 ATS, including 1-5 at home.

Cowboys vs Bills Prediction

Best Bet: DAL +2 (-110)

The NFL’s hottest team outside of the San Francisco 49ers, Dallas has won five straight to grab a share of first place in the NFC East.

The Cowboys have scored at least 33 points throughout the streak, largely thanks to Dak Prescott, the new favorite in the NFL MVP odds.

The Cowboys have been a different team away from AT&T Stadium, where they are 6-1 ATS and 7-0 SU.

Buffalo is coming off a victory over the Kansas City Chiefs and needs every win it can get to keep pace in the AFC. But, until they prove me wrong, I’m going to stick with the Cowboys.

Commanders vs Rams Prediction

Best Bet: LAR -7 (-105)

The Los Angeles Rams’ three-game win streak ended with an overtime loss in Baltimore.

But Matthew Stafford and Co. will get back on track against the Washington Commanders, who continue to sink further into irrelevance.

Washington is allowing a league-worst 379.8 yards and 30.4 per game.

49ers vs Cardinals Prediction

Best Bet: ARI +14 (-115)

The schedule lightens up a tad for San Francisco after a tough divisional game against the Seattle Seahawks.

At 10-3, the 49ers have separated themselves as the clear Super Bowl favorites. However, this could be a spot where they’re caught looking ahead, with a showdown against the Ravens waiting on Christmas Day.

San Francisco will do enough to win, but this game has big backdoor potential.


Doug Bonjour

Doug covered college and prep sports in Connecticut for more than a decade, including stints as the UConn women’s basketball and UConn football beat reporter for Hearst Connecticut Media. During his time reporting on the 11-time national champion Huskies, he covered three NCAA Final Fours. He also has written for the Associated Press and New York Times.

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