Week 10 may not be the NFL’s most attractive slate of games.
Four teams will be on a bye, and three (Kansas City, Miami, Philadelphia) are among the consensus best teams in football.
But Week 10 will still feature a potential Super Bowl preview in Florida. Plus, other teams will be competing for vital playoff positions.
Here’s a look at the Week 10 NFL odds.
NFL Week 10 Odds & Betting Lines
All NFL betting odds cited below are current as of Monday, Nov. 6, and courtesy of DraftKings Sportsbook.
Carolina Panthers @ Chicago Bears
Thursday, Nov. 9, 8:15 p.m. ET
- Moneyline: Panthers (+145) @ Bears (-175)
- Spread: Panthers +3.5 (-110) @ Bears -3.5 (-110)
- Over/Under: Over 40 (-110) / Under 40 (-110)
The Bears should have Justin Fields back for Thursday night, and a win over the Panthers would further improve Chicago’s draft position. The Bears own Carolina’s first-round pick in next year’s draft.
Indianapolis Colts @ New England Patriots
Sunday, Nov. 12, 9:30 a.m. ET
- Moneyline: Colts (-130) @ Patriots (+110)
- Spread: Colts -2 (-110) @ Patriots +2 (-110)
- Over/Under: Over 43.5 (-110) / Under 43.5 (-110)
The Colts defense willed them past the hapless Panthers on Sunday. We’ll see if Indy’s offense can do more in Frankfurt, Germany against the lowly Patriots.
Cleveland Browns @ Baltimore Ravens
Sunday, Nov. 12, 1 p.m. ET
- Moneyline: Browns (+200) @ Ravens (-245)
- Spread: Browns +6 (-110) @ Ravens -6 (-110)
- Over/Under: Over 38.5 (-110) / Under 38.5 (-110)
The Ravens have won four straight and have allowed the fewest points in football (124). But Cleveland is hot on their heels, trailing by just 1.5 games after its 27-0 shellacking of Arizona, and its defense is no slouch either.
San Francisco 49ers @ Jacksonville Jaguars
Sunday, Nov. 12, 1 p.m. ET
- Moneyline: 49ers (-148) @ Jaguars (+124)
- Spread: 49ers -2.5 (-115) @ Jaguars +2.5 (-105)
- Over/Under: Over 44.5 (-110) / Under 44.5 (-110)
Will this be a Super Bowl preview in Duval?
Both teams are coming off their bye in Week 9. For San Francisco, which has dropped three straight, it couldn’t have come at a better time. For Jacksonville, which has won five in row, not so much.
Green Bay Packers @ Pittsburgh Steelers
Sunday, Nov. 12, 1 p.m. ET
- Moneyline: Packers (+142) @ Steelers (-170)
- Spread: Packers +3.5 (-115) @ Steelers -3.5 (-105)
- Over/Under: Over 37 (-110) / Under 37 (-110)
The Steelers are winning with smoke, mirrors, and strong defense. They have been especially effective at home, where they’re 3-1, and should be able to harass Jordan Love and Green Bay’s offense.
New Orleans Saints @ Minnesota Vikings
Sunday, Nov. 12, 1 p.m. ET
- Moneyline: Saints (-142) @ Vikings (+120)
- Spread: Saints -2.5 (-110) @ Vikings +2.5 (-110)
- Over/Under: Over 41 (-110) / Under 41 (-110)
The Saints are back atop the NFC South and have been a much more potent team on offense away from Caesars Superdome. The Vikings have been much better on the road, too, where they’re 4-1, but are just 1-3 at U.S. Bank Stadium.
Houston Texans @ Cincinnati Bengals
Sunday, Nov. 12, 1 p.m. ET
- Moneyline: Texans (+275) @ Bengals (-345)
- Spread: Texans +7 (-105) @ Bengals -7 (-115)
- Over/Under: Over 44.5 (-110) / Under 44.5 (-110)
The Bengals once again look like Super Bowl contenders after beating Buffalo for their fourth straight win and third in a row against an elite team. But Rookie of the Year favorite C.J. Stroud and the Texans are coming to town after their emotional come-from-behind win over Tampa Bay on Sunday.
Tennessee Titans @ Tampa Bay Buccaneers
Sunday, Nov. 12, 1 p.m. ET
- Moneyline: Titans (-102) @ Buccaneers (-118)
- Spread: Titans +1 (-110) @ Buccaneers -1 (-110)
- Over/Under: Over 39.5 (-110) / Under 39.5 (-110)
The Bucs have dropped four straight and are in danger of falling out of the NFC playoff race. Meanwhile, Tennessee occupies last place in the AFC South and is 0-5 in games played away from Nashville.
Both teams need this game badly.
Detroit Lions @ Los Angeles Chargers
Sunday, Nov. 12, 4:05 p.m. ET
- Moneyline: Lions (-122) @ Chargers (+102)
- Spread: Lions -1.5 (-110) @ Chargers +1.5 (-110)
- Over/Under: Over 48.5 (-110) / Under 48.5 (-110)
Detroit will head to SoFi Stadium after its Week 9 bye to square off against the Chargers, who are 2-2 at home this season.
Atlanta Falcons @ Arizona Cardinals
Sunday, Nov. 12, 4:05 p.m. ET
- Moneyline: Falcons (-130) @ Cardinals (+110)
- Spread: Falcons -2.5 (-105) @ Cardinals +2.5 (-110)
- Over/Under: Over 42 (-110) / Under 42 (-110)
This should be the triumphant return of Cardinals quarterback Kyler Murray after he tore his ACL in Week 14 of last season. His reward will be a date with the Falcons, who have dropped two straight but are still in the hunt for the NFC South title.
Washington Commanders @ Seattle Seahawks
Sunday, Nov. 12, 4:25 p.m. ET
- Moneyline: Commanders (+205) @ Seahawks (-250)
- Spread: Commanders +6 (-110) @ Seahawks -6 (-110)
- Over/Under: Over 45 (-110) / Under 45 (-110)
The Seahawks were humbled in their 37-3 loss to Baltimore on Sunday, but they should rebound at home, where they’re 3-1, and will take on the 4-5 Commanders.
New York Giants @ Dallas Cowboys
Sunday, Nov. 12, 4:25 p.m. ET
- Moneyline: Giants (+675) @ Cowboys (-1050)
- Spread: Giants +15.5 (-110) @ Cowboys -15.5 (-110)
- Over/Under: Over 39.5 (-110) / Under 39.5 (-110)
The Cowboys won the first meeting 40-0, and the Giants had Daniel Jones available for the whole game. Dallas has won 11 straight at home, and Tommy DeVito expects to be New York’s quarterback after Jones tore his ACL Sunday.
This could get ugly.
New York Jets @ Las Vegas Raiders
Sunday, Nov. 12, 8:20 p.m. ET
- Moneyline: Jets (-130) @ Raiders (+110)
- Spread: Jets -2.5 (-110) @ Raiders +2.5 (-110)
- Over/Under: Over 36.5 (-110) / Under 36.5 (-110)
The Antonio Pierce era is off to a smashing start after the Raiders’ 30-6 win over the Giants on Sunday. We’ll see if Las Vegas can sweep the New York teams when it hosts the Jets on Sunday Night Football.
Denver Broncos @ Buffalo Bills
Monday, Nov. 13, 8:15 p.m. ET
- Moneyline: Broncos (+300) @ Bills (-380)
- Spread: Broncos +7.5 (-110) @ Bills -7.5 (-110)
- Over/Under: Over 45.5 (-110) / Under 45.5 (-110)
The Bills woke up Monday morning outside the AFC playoff race, which is hard to fathom. But Buffalo is 4-1 at home and should get right against Denver, which occupies 15th place in the AFC despite two straight wins.
NFL Week 10 Betting Trends
Here are some Week 10 betting trends to consider from the 2022 season:
- Favorites finished the week 7-7 straight up.
- Home teams were 9-5 straight up and 8-6 against the spread.
- Home favorites were 6-6 ATS, while home underdogs went 2-0.
- Overs and Unders split the week, going 7-7.